病原微生物學 教授
行政職務:分子醫學病毒研究所所長、病毒緻病及防控教育部重點實驗室副主任
個人介紹：高峰，教授，1961年2月出生，太阳集团app首页分子醫學病毒研究所所長，病毒緻病及防控教育部重點實驗室副主任，博士生導師，國家高層次人才引進計劃創新人才、廣東省珠江傑出人才。高峰教授是知名艾滋病病毒學研究專家，在艾滋病及相關領域研究30餘年，主要研究方向為病毒疫苗、緻病機理、耐藥，溶瘤病毒和胎兒免疫。已發表學術論文200餘篇，在Cell、Nature、Science等世界頂級雜志發表論文15篇，其中第一或通訊作者5篇；應邀綜述和專著章節14篇。截止目前，發表文章經谷歌學者數據庫檢索已被引用>32000次，谷歌學者H因子為84。承擔及參與過多項美國NIH/NIAID艾滋病研究項目，獲批總科研經費超過2100萬美元。在國内承擔國家自然科學基金外國資深學者研究基金團隊項目1項、國家自然科學基金面上項目2項、“十三五”重大科技專項子課題1項、“十四五”重點研發計劃課題1項，獲批總科研經費超過1200萬元。獲授權美國發明專利6項和中國發明專利3項。曾多次應邀在國際會議做邀請報告，主辦或協助舉辦國際艾滋病會議。
1978.09-1984.07 哈爾濱醫科大學（醫學學士）
1984.09-1987.12 中國預防醫學科學院（醫學碩士）
1998.07-2001.09 美國阿拉巴馬大學伯明翰分校（研究助理教授）
1999.06-2001.09 美國阿拉巴馬大學伯明翰分校艾滋病中心（副科學家）
2001.10-2006.09 美國杜克大學（研究副教授）
2006.10-2009.08 美國杜克大學（副教授）
2009.10-2020.09 美國杜克大學（教授）
2010.12-2023.11 吉林大學（教授）
2020.10-現在 美國杜克大學（榮譽教授）
2020.10-現在 太阳集团app首页（教授）
1. Xiaoqian Xin, Yifeng Liu, Lei Guo, Hui Wang, Daiqiang Lu, Yaotian Chang, Mingming Wan, Yong Zhang, Yaming Shan, Qiao Zhang, Xiaowen Liu*, and Feng Gao*. Improvement of B cell responses by an HIV-1 amphiphilic polymer nanovaccine. Nano Letters. 2023 May 10;23(9):4090-4094. PMID: 37120753(*Co-corresponding authors)
2. Hui Wang, Yuqi Liu, Peng Li, Chaowu Liu, Kuibiao Li, Lan Cao, Ying Zhang, Zichun Cheng, Kailing Huang, Zhouxia Zheng, Xiaoqian Xin, Yifeng Liu, Xiaofang Peng, Dan Liang, Bixia Ke, Tao Wang, Qingpei Chen, Weihua Luo, Chaolang Qin, Lihong Sun, Guobing Chen, Oscar Junhong Luo, Jixi Li, Qiao Zhang, Biao Di, Zhoubin Zhang*, Changwen Ke*, Hongling Jia* and Feng Gao*. Emergence of epidemic variants of SARS-CoV-2 by acquiring combinations of new highly mutable nucleotides in its genome. Journal of Infection. 2023 Jun;86(6):588-592. PMID: 36889511(*Co-corresponding authors)
3. Hongling Jia, Hui Wang, Lan Cao, Zhisheng Lai, Zichun Cheng, Qingpei Chen, Tongzheng Liu, Xiangyi Liu, Yanting Wen, Conghui Xu, Weizhi Lu, Guang Yang, Deqian Zhou, Biao Di*, Feng Gao*, Zhicong Yang*. Genetic analysis of a SARS-CoV-2 Omicron variant from a Chinese traveller returning from overseas. Emerg Microbes Infect. 2022 Dec;11(1):306-309. (*Co-corresponding authors) PMCID: PMC8820795
4. Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu , Mark K Loude , Nicole A Doria-Rose, Kevin Wiehe, Alexandra F Nazzari, Adam S Olia, Jason Gorman, Reda Rawi, Wenmin Wu, Clayton Smith, Htet Khant, Natalia de Val, Bin Yu, Junhong Luo, Haitao Niu, Yaroslav Tsybovsky, Huaxin Liao, Thomas B Kepler, Peter D Kwong, John R Mascola, Chuan Qin*, Tongqing Zhou*, Xianghui Yu*, Feng Gao*. Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci. 2022 Mar 23;e2200063. (*Co-corresponding authors) PMID: 35319830
5. Bhavna Hora, Naila Gulzar, Yue Chen, Konstantinos Karagiannis, Fangping Cai, Chang Su, Krista Smith, Vahan Simonyan, Sharaf Ali Shah, Manzoor Ahmed, Ana M. Sanchez, Mars Stone, Myron S. Cohen, Thomas N. Denny, Raja Mazumder, Feng Gao. Streamlined Subpopulation, Subtype, and Recombination Analysis of HIV-1 Half-Genome Sequences Generated by High-Throughput Sequencing. mSphere. 2020 5(5): e00551-20. PMCID: PMC7565892
6. Xiaojun Li, Elena E. Giorgi, Manukumar Honnayakanahalli Marichann, Brian Foley, Chuan Xiao, Xiang-Peng Kong, Yue Chen, Bette Korber and Feng Gao. Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection. Science Advances. 2020 6(27): eabb9153.
7. Xiao C, Li X, Liu S, Sang Y, Gao SJ, Gao F. HIV-1 did not contribute to the 2019-nCoV genome. Emerg Microbes Infect. 2020 9(1):378-381. (*Co-corresponding authors) PMID: 32056509
8. Gao N, Gai Y, Meng L, Wang C, Zhang X, Wang W, Qin C, Yu X*, Gao F*. Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques. Viruses. 2020 12(2):163. (*Co-corresponding authors) PMID: 32023860 PMCID: PMC7077270
9. Blasi M, Stadtler H, Chang J, Hemmersbach-Miller M, Wyatt C, Klotman P, Gao F, Wolfe C, Klotman M. Detection of Donor's HIV Strain in HIV-Positive Kidney-Transplant Recipient. N Engl J Med. 2020. 382(2):195-197. PMID: 31914248
10. Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B, Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF, Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH, McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun. 9(1):1928. 2018. PMID: 29765018; PMC5954121.
11. Bonsignori M, Chen L, Zhou T, Gao F, Sheng Z, Joyce GM, Ozorowski G, Schramm C, Wiehe K, Alam MS, Bradley T, Hwang KK, Luo K, Lu X, Mangiapani M, Iyengar S, Gladden M, Kumar A, Song H, Parks RJ, Acharya P, Bailer RT, Cao A, Chuang GY, Druz A, Georgiev IS, Louder MK, Wu X, Zhang B, Zheng A, Montefiori DC, Michael A. Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber P, Korber BT, Boyd S, Fire AZ, Kepler TB, Mascola JR, Shapiro L, Ward A, Liao HX, Kwong PD, Haynes BF. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimicking Antibody. Cell. 165(2):449-63, 2016. PMID: 26949186
12. Moody MA*, Gao F*, Gurley TC, Amos JD, Kumar A, Hora B, Marshall DJ, Whitesides JF, Xia SM, Parks R, Lloyd KE, Hwang KK, Lu X, Bonsignori M, Finzi A, Vandergrift NA, Alam SM, Ferrari G, Shen X, Tomaras GD, Kamanga G, Cohen MS, Sam NE, Kapiga S, Gray ES, Tumba NL, Morris L, Zolla-Pazner S, Gorny MK, Mascola JR, Hahn BH, Shaw GM, Sodroski JG, Liao HX, Montefiori DC, Hraber PT, Korber BT, Haynes BF*. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe. 18(3):354-62. 2015. (*Co-corresponding authors) PMID: 26355218; PMCID: PMC4567706
13. Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, Liu P, Tay MZ, Seaton KE, Shen X, Foulger A, Lloyd KE, Parks R, Pollara J, Ferrari G, Yu JS, Vandergrift N, Montefiori DC, Sobieszczyk ME, Hammer S, Karuna S, Gilbert P, Grove D, Grunenberg N, McElrath MJ, Mascola JR, Koup RA, Corey L, Nabel GJ, Morgan C, Churchyard G, Maenza J, Keefer M, Graham BS, Baden LR, Tomaras GD, Haynes BF. HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science. 349(6249):aab1253. 2015. PMID: 26229114; PMCID: PMC4562404
14. Gao F*, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF*. Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies. Cell. 158(3):481-91. 2014. (*Co-corresponding authors) PMID: 25065977; PMCID: PMC4150607
15. Liao HX*, Lynch R*, Zhou T*, Gao F*, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program, Becker J, Benjamin B, Blakesley R, Bouffard G, Brooks S, Coleman H, Dekhtyar M, Gregory M, Guan X, Gupta J, Han J, Hargrove A, Ho SL, Johnson T, Legaspi R, Lovett S, Maduro Q, Masiello C, Maskeri B, McDowell J, Montemayor C, Mullikin J, Park M, Riebow N, Schandler K, Schmidt B, Sison C, Stantripop M, Thomas J, Thomas P, Vemulapalli M, Young A, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR, Haynes BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 496:469-76. 2013. (*Equal contribution) PMID: 23552890; PMCID: PMC3637846
16. Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA, Ping LH, Swanstrom R, Tomaras GD, Blattner WA, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Cohen MS, Montefiori DC, Haynes BF, Gaschen B, Athreya GS, Lee HY, Wood N, Seoighe C, Perelson AS, Bhattacharya T, Korber BT, Hahn BH, Shaw GM. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A. 105:7552-7. 2008. PMID: 18490657; PMCID: PMC2387184
17. Cai F, Chen H, Hicks CB, Bartlett JA, Zhu J and Gao F. Detection of minor drug-resistance populations by parallel allele-specific sequencing. Nat. Methods. 4:123-125. 2007. PMID: 17206150; PubMed PMID: 17206150
18. Weaver EA, Lu Z, Camacho ZT, Moukdar F, Liao H-X, Ma B-J, Muldoon M, Theiler J, Nabel GJ, Letvin NL, Korber BT, Hahn BH, Haynes BF and Gao F. Cross-subtype T Cell Immune Responses induced by an HIV-1 Group M Consensus Env Immunogen. J. Virol. 80:6745-6756. 2006. PMID: 16809280; PMCID: PMC1489064
19. Switzer WM, Salemi M, Shanmugam V, Gao F, Cong ME, Kuiken C, Bhullar V, Beer BE, Vallet D, Gautier-Hion A, Tooze Z, Villinger F, Holmes EC and Heneine W. Ancient co-speciation of simian foamy viruses and primates. Nature 17;434(7031):376-80. 2005. PMID: 15772660
20. Bailes E, Gao F, Bibollet-Ruche F, Courgnaud V, Peeters M, Marx PA, Hahn BH, Sharp PM. Hybrid origin of SIV in chimpanzees. Science 300:1713, 2003. PMID: 12805540
21. Gao F, Bhattacharya T, Gaschen, B, Taylor J, Moore JP, Novitsky V, Yusim K, Lang D, Foley B, Beddows S, Alam M, Haynes B, Hahn BH, and Korber B. Consensus and Ancestral State HIV Vaccines (Letter). Science 299:1517-1518. 2003.
22. Gaschen B, Taylor J, Yusim K, Foley B, Gao F, Lang D, Novitsky V, Haynes B, Hahn BH, Bhattacharya T, Korber B. Diversity considerations in HIV-1 vaccine selection. Science 296:2354-60, 2002. PMID: 12089434
23. Santiago M, Rodenburg C, Kamenya S, Bibollet-Ruche F, Gao F, Bailes E, Meleth S, Soong S, Kilby J, Moldoveanu Z, Fahey B, Muller M, Ayouba A, Nerrienet E, McClure H, Heeney J, Pusey A, Collins A, Boesch C, Wrangham R, Goodall J, Sharp P, Shaw GM and Hahn BH. SIVcpz in wild chimpanzees. Science, 295:465, 2002. PMID: 11799233
24. Korber B, Bhattacharya T, Theiler J, Gupta R, Lapedes A, Hahn BH, Gao F, Muldoon M, Wolinsky S. Search for the Origin of HIV and AIDS. Science 289: 1140-1141, 2000.
25. Korber B, Muldoon M, Theiler J, Gao F, Gupta R, Lapedes A, Hahn BH, Wolinsky S and Bhattacharya T. Timing the ancestor of the HIV-1 Pandemic strains. Science 288:1789-1796, 2000. PMID: 10846155
26. Robertson DL, Anderson J, Bradac JA, Carr JK, Foley B, Gao F, Hahn BH, Kuiken C, Learn GH, Leitner T, McCutchan F, Osmanov S, Peeters M, Pieniaze D, Salminen M, Wolinsky S, and Korber B. HIV-1 Nomenclature Proposal. Science 288:55, 2000. PMID: 10766634
27. Gao F, Bailes E, Robertson DL, Chen Y, Rodenburg CM, Michael SF, Cummins LB, Arthur LO, Peeters M, Shaw GM, Sharp PM and Hahn BH. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397:436-441, 1999. PMID: 9989410
28. Gao F, Yue L, White AT, Pappas PG, Barchue J, Hanson AP, Greene BM, Sharp PM, Shaw GM and Hahn BH. Human infection by genetically divers SIVSM related HIV-2 in West Africa. Nature 358:495-499, 1992. PMID: 1641038
29.Mingming Wan, Xiao Yang, Jie Sun, Elena E Giorgi, Xue Ding, Yan Zhou, Yong Zhang, Weiheng Su, Chunlai Jiang, Yaming Shan*, Feng Gao*.Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection. Int J Mol Sci. 2023 Aug 10;24(16):12642.
1. 高峰，第五章-HIV2及SIV的病毒學及生物學，《艾滋病毒感染與艾滋病》，人民衛生出版社，68頁-88頁，1999年。
2. 高峰，第二章-HIV感染的分子流行病學，《艾滋病毒感染與艾滋病》，人民衛生出版社，13頁-32頁，1999年。
1.入選國家第十六批海外引才計劃創新人才長期項目
2.入選2019年“珠江人才計劃”傑出人才項目
專業委員：
中國醫療保健國際交流促進會分子診斷學分會 副主任委員 2022-8-27
中國實驗動物學會免疫與細胞治療專業委員會 副主任委員 2018-12-09
中國性病艾滋病防治協會艾滋病病毒專業委員會 副主任委員 2020-10-16
中國性病艾滋病防治協會基礎研究專業委員會 常務委員 2020-12-16
天津市濱海新區艾滋病疫苗研究會 會長 2020-12-15
專業雜志編委：
One Health Bulletin (Editorial Board) 2021-現在
Animal Models and Experimental Medicine (Editorial Board) 2022-現在
Viruses 2009-現在
中國病毒病雜志 2010-現在
Current HIV Research 2018-現在
PLOS ONE 2019-現在
Zoonotic Diseases 2021-現在
