病理生理學 教授
職稱：教授
學科專業：病理生理學
研究方向：泛素化修飾及膿毒症心功能障礙的發病機制
行政職務：學科建設與發展中心副主任
個人簡介：
王一陽，太阳集团app首页基礎醫與公共衛生學院教授，醫學博士，博士生導師，“暨南雙百英才計劃”。
近年來主要進行泛素化修飾信号通路在炎症和腫瘤等疾病發生發展過程中的作用機制研究。主持國家自然科學基金面上項目，獲得暨南雙百英才計劃資助。在國内外優秀雜志發表論文20餘篇，其中包括第一或通訊作者在Nature Communications，Science Advances，J Am Chem Soc，Cell Chemical Biology，FASEB J，Critical Care等一區或Top論文近10篇，擔任SCI雜志Cardiology Research and Practice的編委。主持教改項目兩項。
2007至2013年于太阳集团app首页醫學院病理生理學系攻讀碩士和博士學位，主要進行膿毒症性心功能障礙方面的研究。
2013年博士畢業之後到美國喬治亞州立大學進行了三年的博士後研究工作，研究内容是通過對泛素化系統的改造，發現某些泛素連接酶E3的特異性靶蛋白。相關研究已經分别發表于Nature Communications和Science Advances。此後于2016年底到2018年7月，在美國Scripps研究所Peter Schultz院士課題組繼續進行博士後的研究工作，主要進行針對治療癌症的免疫檢查點藥物的開發與研究。合成了抗PD-L1/CTLA4抗體與小分子化合物的複合體；針對大腸杆菌E. coli基因組學的研究，發現了能誘導基因組DNA突變成RNA的基因，相關成果發表于雜志JACS(《美國化學會志》)。于2018年7月，通過太阳集团app首页人才引進政策，進入太阳集团app首页基礎醫學院病理生理學系任教。
1. Yiyang Wang, Xianpeng Liu, Li Zhou, Duc Duong, Karan Bhuripanyo, Bo Zhao, Han Zhou, Ruochuan Liu, Yingtao Bi, Hiroaki Kiyokawa, Jun Yin. Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nature Communications. 2017, 8 (1): 2232.
2. Karan Bhuripanyo, Yiyang Wang, Xianpeng Liu, Li Zhou, Ruochuan Liu, Bo Zhao, Yingtao Bi, Han Zhou, Geng Chen, Nicholas T. Seyfried, Walter J.Chazin, Hiroaki Kiyokawa, Jun Yin. Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer. Science Advances. 2018, 4 (1): e1701393.
3. Angad P. Mehta, Yiyang Wang, Sean A. Reed, Lubica Supekova, Tsotne Javahishvili, John C. Chaput, Peter G. Schultz. Bacterial Genome Containing Chimeric DNA-RNA Sequences. J Am Chem Soc. 2018, 140 (36): 11464-11473.
4. Yiyang Wang, Shuai Fang, Geng Chen, Rakhee Ganti, Tatiana A. Chernova, Li Zhou, Duc Duong, Hiroaki Kiyokawa, Ming Li, Bo Zhao, Natalia Shcherbik, Yury O. Chernoff, and Jun Yin. Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer. Cell Chem Biol. 2021, 28(9):1283-1297.
5. Yiyang Wang, Ruochuan Liu, Jia Liao, Lucen Jiang, Geon H Jeong, Li Zhou, Monica Polite, Duc Duong, Nicholas T Seyfried, Huadong Wang, Hiroaki Kiyokawa, Jun Yin. Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-γ dependent apoptosis of cervical cancer cells. FASEB J. 2021, 35(11): e21986.
6. Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang. Dexmedetomidine Promotes LPS-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through alpha2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice. Int J Mol Sci, 2021, 22: 12749.
7. Lucen Jiang, Jia Liao, Jianghuan Liu, Qingzhu Wei, Yiyang Wang. Geranylgeranylace -tone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP. J Cell Mol Med. 2021, 25(16): 7961-7972.
8. Yiyang Wang, Yuan Wang, Duomeng Yang, Xiaohui Yu, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation, Critical Care, 2015, 19 (1): 76.
9. Yiyang Wang, Hong-mei Li, Hua-dong Wang, Xuemei Peng, Yanping Wang, Daxiang Lu, Renbin Qi, Chaofeng Hu, Jianwei Jiang. Pretreatment with Berberine and Yohimbine Protects Against LPS-Induced Myocardial Dysfunction Via Inhibition of Cardiac I-κBα Phosphorylation and Apoptosis in Mice. Shock, 2011.11.3, 35(3): 322-328.
10. Yiyang Wang, Xiaohui Yu, Faqiang Wang, Yuan Wang, Yanping Wang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockage of presynaptic α2A-adrenergic receptor. PLoS One. 2013; 8 (5): e63622.
11. Hongmei Li, Yiyang Wang, Huadong Wang, Wenjuan Cao, Xiaohui Yu, Daxiang Lu, Ren-bin Qi, Chaofeng Hu, Yuxia Yan. Berberine protects against Lipopolysaccharide induced intestinal injury in m ice in an alpha 2 adrenoceptor independent manner. Acta Pharmacol Sin , 2011, 32(11): 1364 1372.
12. Hui Li, Yiyang Wang, Haoqing Zhang, Baoyin Jia, Daan Wang, Hongmei Li, Daxiang Lu, Renbin Qi, Yuxia Yan, Huadong Wang. Yohimbine enhances protection of berberine against LPS-induced mouse lethality through multiple mechanisms. PLoS One. 2012, 7 (12): e52863.
《中華創傷休克學》（參編）
2020年太阳集团1088vip優秀科研工作者
擔任SCI雜志Cardiology Research and Practice的編委
