齊琦

藥理學 教授

個人簡介


職稱:教授

學科專業:藥理學

研究方向:小分子/多肽藥物活性及機制研究;抗腫瘤化合物篩選,活性及機制研究;腫瘤相關蛋白功能及信号傳導通路方面的研究;基于蛋白-蛋白相互作用的靶标的發現和研究

行政職務:靶向臨床藥物轉化中心副主任

電子郵箱:qiqikc@jnu.edu.cn

個人介紹:

齊琦,太阳集团app首页基礎醫學院與公共衛生學院藥理學系,教授,博導。緻力于藥理學及腫瘤細胞生物學研究。迄今為止(2024)發表論文123篇,SCI論文105篇,H指數42。其中包括國際知名雜志PNAS, Mol Psychiatry, Adv Sci, Acta Pharm Sin B, Redox Biol,Oncogene在内SCI第一/通訊作者論文40篇。研究成果獲得國内外同行的廣泛關注和高度肯定。現是包括Cancer research,Drug Resistance Updates,Cancer letters,Acta Pharmaceutica Sinica B,Journal of Advanced Research,Journal of Experimental & Clinical Cancer Research在内的40家SCI收錄雜志的特邀審稿人。Molecular and Cellular Biochemistry(二區), Biochemical Pharmaocology(二區,TOP)編委,《中國臨床藥理學及治療學》編委;《腫瘤藥理學》(2008,北京,化學工業出版)《藥理學》(2021,北京,中國醫藥科技出版社)教材編委。主持國家自然科學基金面上項目兩項,廣東省自然科學基金一項,廣州市基礎與應用基礎研究項目一項。國家自然科學基金和廣東省自然科學基金評審專家。中國抗癌協會抗癌藥物專業委員會青年委員會副主任委員,廣東省藥理學會腫瘤藥理學專業委員會常務委員,廣東省藥理學會藥物篩選與評價專業委員會常務委員,廣東省抗癌協會抗腫瘤藥物專業委員會委員,美國癌症研究協會,國際化學生物學學會,中國細胞生物學學會,中國藥理學會及中國生物化學與分子生物學會會員。


學習經曆


2006-2009,中國藥科大學,藥理學博士學位

2003-2006,中國藥科大學,藥理學碩士學位

1999-2003,鄭州大學,藥學學士學位


工作經曆


2018.6-至今,太阳集团1088vip藥理系 教授

2016.11-2018.5,埃默裡大學醫學院藥理系化學生物學研發中心 Instructor (美國)

2015.3-2016.10,埃默裡大學醫學院藥理系化學生物學研發中心Research Associate (美國)

2010.8-2015.2,埃默裡大學醫學院病理和實驗醫學系博士後(美國)

2009.8-2010.7,西弗吉尼亞大學醫學院生理系倫道夫瑪麗巴布癌症中心博士後(美國)


主要論文


近五年SCI論文

1. Zou Q Zhou X, Lai J, Zhou H, Su J, Qi Q et al. Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. Redox Biol. 2024 Dec 4.103460. (通訊作者,一區)

2. Fan S, Yan X, Hu X, Liu X, Qi Q, Chen Y et al. Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3β/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1α. J Exp Clin Cancer Res. 2024 Jun 27;43(1):180. (通訊作者,一區)

3. Lai JQ, Zhao LL, Hong C, Zou QM, Su JX, Qi Q et al. Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis. Acta Pharmacol Sin. 2024 Aug;45(8):1715-1726. (通訊作者,一區)

4. Tu H, Zhou X, Zhou H, Luo Z, Yan Y, Luo Z, Qi Q. Anti-tumor effect and mechanisms of Timosaponin AIII across diverse cancer progression. Biochem Pharmacol. 2024 Oct;228:116080. (通訊作者,二區TOP

5. Fan S, Qi M, Qi Q, Miao Q, Zhang D, Ye W, Chen M et al. Targeting FAP α-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis. Acta Pharm Sin B. 2024 Feb;14(2):682-697. (第一作者,一區)

6. Wang F, Qi Q, Qin B, Li K, Jiang Z, Zhang H et al. Targeting VCP potentiates immune checkpoint therapy for colorectal cancer. Cell Rep. 2023 Qct 21;42(11):113318. (第一作者,一區)

7. Li X, Qi Q, Li Y, Chen M, Ye W, Zhang D et al. TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel. Adv Sci. 2023 Aug 27;e2302717. (第一作者,一區)

8. Wang C, Yu C, Chang H, Song J, Qi Q, Shan C et al. Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer. Expert Opin Ther Targets. 2023 Jul-Dec;27(8):733-743. (通訊作者,二區)

9. Luo H, Zhang C, He L, Qi Q, Chen JX, Yao W et al. 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype. Psychopharmacology. 2023 Sep;240(9):1947-1961. (通訊作者,二區)

10. Su JX, Li SJ, Zhou XF, Zhang ZJ, Yan Y, Liu SL, Qi Q. Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies. Acta Pharmacol Sin. 2023 Sep;44(9):1725-1736. (通訊作者,一區)

11. Zhang Y, Song Y, Ren S, Qi Q, Shen X, Chen Y et al. GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells. Oncogene. 2023 Jan;42(3):184-197. (通訊作者,一區)

12. Cao Q, Luo S, Yao W, Chen J, Hashimoto K, Qi Q, Zhang JC et al. Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. Mol Ther Nucleic Acids. 2022 Sep 13;29:1-15. (通訊作者,一區)

13. Yao W, Cao Q, Luo S, He L, Yang C, Chen J, Qi Q, Hashimoto K, Zhang JC. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Mol Psychiatry. 2022 Mar;27(3):1618-1629. (通訊作者,一區)

14. Tang R, Cao QQ, Hu SW, Sun YR, Zhang JC, Qi Q et al. Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Acta Pharmacol Sin. 2022 Apr;43(4):829-839. (通訊作者,一區)

15. Liu C, Yang D, Wang H, Hu S, Xie X, Zhang L, Jia H, Qi Q. MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease. Mol Cell Biochem. 2021 Dec;476(12):4245-4263. (通訊作者,二區)

16. Li CL, Li J, Gong S, Huang M, Qi Q, Yin X et al. Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis. Acta Pharmacol Sin. 2021 Nov;42(11):1847-1859. (通訊作者,一區)

17. Li Z, Su J, Sun M, Song J, Shan C, Qi Q, Zhang S et al. Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer. Mol Cell Biochem. 2021 Sep;476(9):3423-3431. (通訊作者,二區)

18. Yao W, Lin S, Su J, Hashimoto K, Qi Q, Zhang JC et al. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Transl Psychiatry. 2021 Feb 24;11(1):140. (通訊作者,一區)

19. Xu M, Qi Q, Men L, Wang S, Li M, Xiao M, Chen X, Wang S, Wang G, Jia H, Liu C. Berberine protects Kawasaki disease-induced human coronary artery endothelial cells dysfunction by inhibiting of oxidative and endoplasmic reticulum stress. Vascul Pharmacol. 2020 Apr;127:106660. (第一作者,二區)

20. Li X, Tang X, Su J, Xu G, Zhao L, Qi Q. Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid. Biochem Pharmacol. 2019 Sep 9;169:113635. (通訊作者,二區TOP


學術著作


1.《Renin-Angiotensin in Cancer, Lung, Liver and Infectious Diseases》2022, “Advances in Biochemistry in Health and Disease”Book Series, Springer Nature Switzerland AG, 參編;

2.《藥理學》2021,“十四五”規劃教材,北京,中國醫藥科技出版社,參編;

3.《腫瘤藥理學》2008,“研究生教材”北京,化學工業出版, 參編


獲獎及榮譽 


Acta Pharmacologica Sinica (A1一區) 優秀審稿人獎 2022

Acta Pharmacologica Sinica  優秀審稿人獎 2022

Acta Pharmacologica Sinica 優秀審稿人獎 2018

Acta Pharmacologica Sinica  優秀審稿人獎 2016 


學術兼職


受邀評審專家

國家自然科學基金

廣東省自然科學基金

湖南省自然科學基金

江西省自然科學基金

廣西自然科學基金


雜志編委

《Molecular and Cellular Biochemistry》

《Biochemical Pharmacology》

《中國臨床藥理學與治療學》


受邀40家SCI收錄雜志審稿人 

Cancer Research (12.701); Drug Resistance Updates (15.8); Journal of Advanced Research (11.4); Acta Pharmaceutica Sinica B (11.403); Journal of Experimental & Clinical Cancer Research (11.161); Cancer letters (8.679); International Journal of Biological Macromolecules (7.70); Cell Death & Disease (8.469); Free Radical Biology and Medicine (7.376), Oxidative Medicine and Cellular Longevity (7.31), Food and Chemical Toxicology (6.026); Acta Pharmacologica Sinica (6.15); Biomedicine&Pharmacotherapy (6.9); Biochemical Pharmacology (5.858); Cell Death Discovery (5.241); Laboratory Investigation (5.662); Phytomedicine (5.34); Journal of Molecular Medicine (4.599); Journal of Cellular and Molecular Medicine (5.31); Frontiers in Pharmacology (5.81); Journal of Ethnopharmacology (4.8); Molecular Pharmacology (4.436); Investigational New Drugs (3.85); BMC Cancer (4.43); International Immunopharmacology (4.8); Journal of Oncology (4.375); Toxicology (4.221); Cancer Management and Research (3.989); Basic &Clinical Pharmacology & Toxicology (4.08);  OncoTargets and Therapy (4.147); Journal of Cellular Biochemistry (4.429); European Journal of Pharmacology (4.432); PLOS One (2.806); Molecular and Cellular Biochemistry (3.396); Pharmacological Reports (2.587); Oncology Letters (3.24); Molecular Medicine Reports (2.952); Gene (2.6); Neoplasma (2.575);