個人簡介

職稱：教授

學科專業：藥理學

研究方向：溶瘤病毒療法，腫瘤免疫治療。

電子郵箱：zhanghp@jnu.edu.cn

個人簡介：張海鵬，太阳集团1088vip，教授，博導，珠江科技新星。主持包括國家自然科學基金面上項目等科研項目7項，授權國際、中國專利8項；研究領域集中在溶瘤病毒療法和以外泌體為載體的腫瘤靶向治療等轉化醫學研究。近年來，以通訊或第一作者發表論文于Science Translational Medicine、Nature Communications、PNAS、Molecular Therapy等國際知名雜志，相關學術成果被《Nature Reviews》專題評述。

學習經曆

2005.9~2009.7， 山東大學，藥   學，學士 

2009.9~2014.6， 中山大學，藥理學，博士

2014.9~2017.12，中山大學，博士後

工作經曆

2018.1~至今，太阳集团app首页，基礎醫學與公共衛生院，藥理學系，教授

主要論文

1. Zhang, H.#, Li, K.#, Lin, Y.#, Xing, F., Xiao, X., Cai, J., Zhu, W., Liang, J., Tan, Y., Fu, L., Wang, F., Yin, W., Lu, B., Qiu, P., Su, X., Gong, S., Bai, X., Hu, J.*, and Yan, G.*. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Science Translational Medicine. 2017, 9(404). (第一作者，IF：17.2，中科院分區TOP期刊). Highlighted in Science Translational Medicine. Comments in Nature Reviews|gastroenterology＆hepatology.

2. Xiao, X.#, Liang, J.#, Huang, C., Li, K., Xing, F., Zhu, W., Lin, Z., Xu, W., Wu, G., Zhang, J., Lin, X., Tan, Y., Cai, J., Hu, J., Chen, X., Huang, Y., Qin, Z., Qiu, P., Su, X., Chen, L., Lin, Y. *, Zhang, H.*, and Yan, G.*. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nature Communications. 2018, 9(1):4342.（共同通訊作者，IF：11.878，中科院分區TOP期刊）

3. Lin, Y. #, Zhang, H.#, Liang, J.#, Li, K., Zhu, W., Fu, L., Wang, F., Zheng, X., Shi, H., Wu, S., Xiao, X., Chen, L., Tang, L., Yan, M., Yang, X., Tan, Y., Qiu, P., Huang, Y., Yin, W., Su, X., Hu, H., Hu, J.*, and Yan, G.*. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. PNAS. 2014, 111(42):E4504-4512.（共同第一作者，IF：9.58，中科院分區TOP期刊）

4. Li, K.#, Zhang, H.#, Qiu, J., Lin, Y., Liang, J., Xiao, X., Fu, L., Wang, F., Cai, J., Tan, Y., Zhu, W., Yin, W., Lu, B., Xing, F., Tang, L., Yan, M., Mai, J., Li, Y., Chen, W., Qiu, P., Su, X., Gao, G., Tai, P. W., Hu, J.*, and Yan, G.*. Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1. Molecular Therapy. 2016, 24(1):156-165.（共同第一作者，IF：8.402，中科院分區TOP期刊）

5. Li, K.#, Hu, C.#, Xing, F.#, Gao, M., Liang, J., Xiao, X., Cai, J., Tan, Y., Hu, J., Zhu, W., Yin, W., Li, Y., Chen, W., Lu, B., Mai, J., Qiu, P., Su, X., Yan, G., Zhang, H.*, and Lin, Y.*. Deficiency of the IRE1alpha-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1. Journal of Virology. 2018, 92(6).（共同通訊作者，IF：4.324，中科院分區TOP期刊）

6. Tan, Y. #, Lin, Y. #, Li, K., Xiao, X., Liang, J., Cai, J., Guo, L., Li, C., Zhu, W., Xing, F., Mai, J., Gu, J., Tan, X., Yin, W., Lu, B., Qiu, P., Su, X., Gao, M., Hu, J., He, S., Lu, L., Gong, S., Yan, G., and Zhang, H.*. Selective Antagonism of Bcl-xL Potentiates M1 Oncolysis by Enhancing Mitochondrial Apoptosis. Human Gene Therapy. 2018, 29(8):950-961.（通訊作者，IF：3.855）

7. Zhang, H.#, Lin, Y.#, Li, K., Liang, J., Xiao, X., Cai, J., Tan, Y., Xing, F., Mai, J., Li, Y., Chen, W., Sheng, L., Gu, J., Zhu, W., Yin, W., Qiu, P., Su, X., Lu, B., Tian, X., Liu, J., Lu, W., Dou, Y., Huang, Y., Hu, B., Kang, Z., Gao, G., Mao, Z., Cheng, S. Y., Lu, L., Bai, X. T., Gong, S., Yan, G., and Hu, J.*. Naturally Existing Oncolytic Virus M1 Is Nonpathogenic for the Nonhuman Primates After Multiple Rounds of Repeated Intravenous Injections. Human Gene Therapy. 2016, 27(9):700-711.（第一作者，IF：3.855）

8. Cai, J.#, Lin, Y.#, Zhang, H., Liang, J., Tan, Y., Cavenee, W. K.*, and Yan, G.*. Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics. PNAS. 2017, 114(26):6812-6817. （IF：9.58）

9. Liang, J.#, Guo, L.#, Li, K., Xiao, X., Zhu, W., Zheng, X., Hu, J., Zhang, H., Cai, J., Yu, Y., Tan, Y., Li, C., Liu, X., Hu, C., Liu, Y., Qiu, P., Su, X., He, S., Lin, Y.*, and Yan, G.*. Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus. Nature Communications. 2018, 9(1):1524.（IF：11.878）

10. Xing, F.#, Luan, Y.#, Cai, J.#, Wu, S., Mai, J., Gu, J., Zhang, H., Li, K., Lin, Y., Xiao, X., Liang, J., Li, Y., Chen, W., Tan, Y., Sheng, L., Lu, B., Lu, W., Gao, M., Qiu, P., Su, X., Yin, W., Hu, J., Chen, Z., Sai, K., Wang, J., Chen, F., Chen, Y., Zhu, S., Liu, D., Cheng, S., Xie, Z.*, Zhu, W.*, and Yan, G.*. The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Reports. 2017;18:468-481.（IF：7.815）

學術著作

獲獎及榮譽 

廣州市“珠江科技新星” （2019年度）

廣東省傑出青年基金（2021年度）

學術兼職

中國抗癌協會會員；

中國藥理學會會員；

中國病理生理學會會員；

《Cancer management and research》和《Acta Pharmacologica Sinica》期刊審稿人；