醫學生物化學與分子生物學系 研究員
職稱：研究員
學科專業：生物化學和分子生物學
研究方向：腫瘤代謝重編程的分子病理機制及應對策略研究
行政職務：副院長
電子郵箱：fanjun@jnu.edu.cn
個人介紹：2008年在中國科學技術大學獲得博士學位，2008-2012年在美國埃默裡大學（EMORY UNIVERSITY）血液病和臨床腫瘤學系完成博士後研究工作并于2012年起任講師，2015年至2018年受聘于埃默裡大學醫學院任助理教授（Tenure Track)，2018年全職回國工作。主要從事腫瘤和白血病細胞代謝重編程的分子機制研究和針對新型靶點的小分子藥物研發工作。以通訊作者和第一作者在Molecular Cell (2011, 2014a, 2014b, 2015, 2016), Nature Cell Biology (2015), Cell Metabolism (2017), Signal Transduction and Targeted Therapy (2020), European Respiratory Journal (2022)，Cancer Communications (2021), Frontiers in Pharmacology (2021) 等期刊上發表學術論文。研究工作先後獲得美國癌症協會(American Cancer Society, ACS)培養計劃和美國癌症傑出研究專項基金(Specialized Programs of Research Excellence, SPORE)培養計劃，國家自然科學基金，廣東省自然科學基金，廣東省重大人才工程高層次人才引進項目的資助。
2004.02-2008.06中國科學技術大學，博士
2018.06-至今，太阳集团1088vip，研究員，副院長。
2015.01-2018.06，美國埃默裡大學醫學院放射腫瘤學系，助理教授（Tenure Track)。
2012.06-2015.01，美國埃默裡大學醫學院血液病和醫學腫瘤學系，講師。
2008.10-2012.06，美國埃默裡大學醫學院血液病與醫學腫瘤學系，博士後研究員。
通訊作者文章：
[1]Xie, X., Wu, F., Tian, J., Liu, Z., He, H., Bao, D., Li, G., Li, H., Chen, J., Lai, Y., Chen, Z., Fan, J.*, Chen, G.*, Lai, C.*, 2022. Pyrocatechol Alleviates Cisplatin-Induced Acute Kidney Injury by Inhibiting ROS Production. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022, 2158644. https://doi.org/10.1155/2022/2158644.（IF: 7.3）.
[2]Jia, H., Liu, C., Li, D., Huang, Q., Liu, D., Zhang, Y., Ye, C., Zhou, D., Wang, Y., Tan, Y., Li, K., Lin, F., Zhang, HQ, Lin, J., Xu, Y., Liu, J., Zeng, Q., Hong, J., Chen, G., Zhang, H, Zheng, L., Deng, X., Ke, C., Gao, Y.*, Fan, J.*, Di, B.*, Liang, H.*, 2022. Metabolomic analyses reveal new stage-specific features of COVID-19. EUROPEAN RESPIRATORY JOURNAL 59(2): 2100284. https://doi.org/10.1183/13993003.00284-2021.（IF:.33.8，1區 TOP期刊）.
[3]Yan, L., Tan, Y., Chen, G., Fan, J.*, Zhang, J.*, 2021b. Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22, 10268. https://doi.org/10.3390/ijms221910268.（IF:6.2，2區 TOP期刊）.
[4]Yan, L., Liu, Y., Ma, X., Hou, D., Zhang, Y., Sun, Y., Shi, S., Forouzanfar, T., Lin, H.*, Fan, J.*, Wu, G.*, 2021a. Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells. FRONTIERS IN PHARMACOLOGY 12: 670081. https://doi.org/10.3389/fphar.2021.670081. （IF:5.8，2區 TOP期刊）.
[5]Tian, L., Chen, C., Guo, Y., Zhang, F., Mi, J., Feng, Q., Lin, S., Xi, N., Tian, J., Yu, L., Chen, Y., Cao, M., Lai, C.*, Fan, J.*, Zhang, Y.*, Chen, G.*, 2021. mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer. NEOPLASIA. 23, 643–652. https://doi.org/10.1016/j.neo.2021.05.007.（F:6.3，2區）.
[6]Tian, T., Fan, J.*, Elf, S.*, 2021. Metabolon: a novel cellular structure that regulates specific metabolic pathways. CANCER COMMUNICATIONS 41, 439–441. https://doi.org/10.1002/cac2.12154.（IF:15.2，1區 TOP期刊）.
[7]Di, B., Jia, H., Luo, O., Lin, F., Li, K., Zhang, Y., Wang, H., Liang*, H., Fan, J.*, Yang, Z.*, 2020. Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics. SIGNAL TRANSDUCTION AND TARGETED THERAPY 5, 217 (2020). https://doi.org/10.1038/s41392-020-00333-1.（IF:38，1區 TOP期刊）.
[8]Zhang, H., Quan, Q., Zhang, M., Zhang, N., Zhang, W., Zhan, M., Xu, W., Lu, L.*, Fan, J.*, Wang, Q.*, 2020b. Occurrence of bisphenol A and its alternatives in paired urine and indoor dust from Chinese university students: Implications for human exposure. CHEMOSPHERE 247: 125987. https://doi.org/10.1016/j.chemosphere.2020.125987.（IF:8.9，2區 TOP期刊）.
[9]Zhang, H., Quan, Q., Li, X., Sun, W., Zhu, K., Wang, X., Sun, X., Zhan, M., Xu, W., Lu, L.*, Fan, J.*, Gao, Y.*, 2020a. Occurrence of parabens and their metabolites in the paired urine and blood samples from Chinese university students: Implications on human exposure. ENVIRONMENTAL RESEARCH 183: 109288. https://doi.org/10.1016/j.envres.2020.109288. （IF:8.4，2區 TOP期刊）.
[10]Xia, S., Lin, R., Jin, L., Zhao, L., Kang, H., Pan, Y., Liu, S., Qian, G., Qian, Z., Konstantakou, E., Zhang, B., Dong, J., Chung, Y., Abdel-Wahab, O., Merghoub, T., Zhou, L., Kudchadkar, R., Lawson, D., Khoury, H., Khuri, F., Boise, L., Lonial, S., Lee, B., Pollack, B., Arbiser, J., Fan, J.*, Lei, Q.*, Chen, J.*, 2017. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. CELL METABOLISM 25, 358–373. https://doi.org/10.1016/j.cmet.2016.12.010.（IF:31，1區 TOP期刊）.
[11]Lin, R.-T., Elf, S., Shan, C., Kang, H.-B., Shan, C., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.H, Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., Jiang,L., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, Z.G., Hurwitz,S.J., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Lei, Q.-Y., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S. *, Fan, J. *, and Chen, J*. 2015. 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. Nature Cell Biology. 17, 1484–1496 (2015). doi:10.1038/ncb3255.（IF:28，1區 TOP期刊）.
[12]Shan, C., Kang, H.-B., Elf, S., Xie, J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M., Boggon, T. and Fan, J.* 2014.Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. 2014, 289:21413-21422. doi: 10.1074/jbc.M114.581124.（IF:4.1，2區 TOP期刊）.
[13]Shan, C., Elf, S., Ji, Q., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J. *, and Chen, J*. 2014. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell 21; 55(4):552-65. doi: 10.1016/j.molcel.2014.06.020.（IF:19.3，1區 TOP期刊）
第一作者文章：
[1]範駿, 翻譯後修飾與腫瘤代謝重編程, 中山大學學報(醫學科學版), 2022, 43(02): 161-172. (特邀綜述) （中文核心期刊）
[2]Fan, J., Lin, R., Xia, S., Chen, D., Elf, S., Liu, S., Pan, Y., Xu, H., Shan, C., Zhou,L., Lei,Q., Li,Y., Mao, H., Lee, B.H., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Gaddh, M., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W.J. and Chen, J*. 2016. Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor growth. Molecular Cell 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014.（IF:19.3）.
[3]Fan, J., Shan, C., Kang, H.-B.*, Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. 2013. Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell 2014 20;53(4):534-48. doi: 10.1016/j.molcel.2013.12.026.（IF:19.3）.
[4]Kang, H.-B. *, Fan, J. *, Lin, R.-T.*, Elf, S., Ji, Q., Seo, J.H., Arbiser, J., Cohen, C Brat, D, Miziorko, H.M., Abdel-Wahab, O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D.A., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., He, C., Kang, S., and Chen, J. 2015. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell 2015 6;59(3):345-358. doi:10.1016/j.molcel.2015.05.037.（IF:19.3）
[5]Fan, J., Shan, C., Kang, H.-B., Elf, S., Hitosugi, T., Xie, J., Tucker, M., Gu, T.-L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., and Chen, J.* 2014. Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J. Biol. Chem. 2015 6;59(3):345-358. doi:10.1074/jbc.M114.593970. （IF:4.125）
[6]Hitosugi, T.*, Fan, J.*, Chung, T.W.*, Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S., and Chen, J. 2011, Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 2011 23;44(6):864-77.（IF:19.3）
[7]Fan, J., Hitosugi, T., Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Khuri, F.R., Kang, S., and Chen, J. 2011. Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Mol. Cell. Biol. 2011 31(24):4938-50. (Selected as a Spotlight Article by Editors).（IF:4.398）
[8]Fan, J., Ren, H-G, Fei, E-K, Jia, N-L, Ying, Z., Jiang, P., Wu, M. Wang, G-H DJ-1(K130R), the sumoylation-deficient mutant fails to decrease Bax. 2008. FEBS Letters Apr2;582(7):1151-6.（IF:3.623）
[9]Fan, J., Ren, H.-G., Jia, N.-L., Fei, E.-K., Zhou, T., Jiang, P., Wu, M. Wang, G.-H, DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J. Biol. Chem (2008) Feb 15; 283(7):4022-30.（IF:4.125）
參與發表論文：
[1]李佳琪,孫勇,李樂,等. PDHA1促進三陰性乳腺癌細胞的增殖、侵襲和轉移 [J]. 中國病理生理雜志, 2024, 40 (02): 244-254.
[2]Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie. ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17. Acta Pharmaceutica Sinica B. 2023, 13(12): 4840-4855. https://doi.org/10.1016/j.apsb.2023.07.006.
[3]Yanguan Guo, Jiaxin Tian, Yongjian Guo, Cong Wang, Congcong Chen, Songwang Cai, Wenliang Yu, Binghe Sun, Jin Yan, Zhonghua Li, Jun Fan, Qi Qi, Dongmei Zhang, Weilin Jin, Zichun Hua, Guo Chen. Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin. Cell Reports. Volume 42, Issue 12, 2023, 113511, https://doi.org/10.1016/j.celrep.2023.113511.
[4]Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. Boise, Taofeek K. Owonikoko, Fadlo R. Khuri, Kelly R. Magliocca, Dong M. Shin, Sagar Lonial, and Sumin Kang. (2018) MAST1 drives cisplatin resistance in human cancers by rewiring cRaf independent MEK activation. Cancer Cell (2018) Aug 13;34(2):315-330.e7. doi: 10.1016/j.ccell.2018.06.012. Epub 2018 Jul 19
[5]Zhao L, Fan J, Xia S, Pan Y, Liu S, Qian G, Qian Z, Kang HB, Arbiser JL, Pollack BP, Kudchadkar RR, Lawson DH, Rossi M, Abdel-Wahab O, Merghoub T, Khoury HJ, Khuri FR, Boise LH, Lonial S, Chen F, Chen J, Lin R. HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers. J Biol Chem. 2017 Jun 16;292(24):10142-10152. doi: 10.1074/jbc.M117.788778. Epub 2017 May 3. PubMed PMID: 28468827.
[6]Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 36, 3797-3806 (2017). doi: 10.1038/onc.2017.6. PubMed PMID: 28218905.
[7]Elf, S., Lin, R., Xia, S., Pan, Y., Shan, C., Wu, S., Lonial, S., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., Fan, J., and Chen, J. (2016) Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to anti-malarial agent dihydroartemisinin. Oncogene 36, 254-262. doi: 10.1038/onc.2016.196.
[8]Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006. PubMed PMID: 25670081; PubMed Central PMCID: PMC4325424.
[9]Wang, J., Luo, C., Shan, C., Elf, S., Lu, Y., Zhou, Y., Wen, Y., Vinkenborg, J.L., Fan, J., Kang, H., Han, D., Karpus, J., Xie, Y., Ouyang, S., Luan, C., Zhang, N., Merkx, M., Liu, H., Chen, J., Jiang, H., He, C. (2015) Inhibition of human copper trafficking significantly attenuates tumor growth. Nature Chemistry 7, 968–979. doi:10.1038/nchem.2381.
[10]Li, D., Jin, L., Alesi, G.N., Kim, Y.M., Fan, J., Seo, J.H., Wang, D., Tucker, M., Gu, T.-L., Lee, B.-H., Taunton, J., Magliocca, K.R., Chen, Z.G., Shin, D.M., Khuri, F.R., Kang, S. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J. Biol. Chem. 2013 Nov 8;288(45) Epub 2013 Oct 1. doi: 10.1074/jbc.M113.500561.
[11]Jin, L., Li, D., Lee J.-S., Elf, S., Alesi, G.N., Fan, J., Kang, H.-B., Wang, D., Fu, H., Taunton, J., Boggon, T.J., Tucker, M., Gu, T.L., Chen, Z.G., Shin, D.M., Khuri F.R., and Kang, S. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol. Cell. Biol. 2013 Jul;33(13):2574-85. Epub 2013 Apr 22. doi: 10.1128/MCB.01677-12.
[12]Hitosugi, T., Zhou, L., Fan, J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T.-L., Aleckovic, M., LeRoy, G., Kang, Y., Kang, H.-B., Seo, J.H., Shan, C., Jin, P., Gong, W., Lonial, S., Arellano, M., Khoury, H.J., Chen, G.Z., Shin, D.M., Khuri, F.R., Boggon, T.J., Kang, S., He, C., and Chen, J. (2013) Y26 phosphorylation of PGAM1 provides a metabolic advantage to tumors by stabilizing the active conformation. Nature Communications 4, Article number:1790; doi:10.1038/ncomms2759
[13]Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H.-B., Seo, J.H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T.-L., Jin, P., Aleckovic, M., LeRoy, G., Kang, Y., Sudderth, J.A., DeBerardinis R.J., Luan, C., Chen, G.Z., Muller, S.M., Shin, D.M., Owonikoko, T.K., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Ye, K., Boggon, T.J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. doi: 10.1016/j.ccr.2012.09.020. PMID: 23153533; PMCID: PMC3500524.
[14]Zhang, T., Wang,P., Ren, H.-G., Fan, J., Wang, G.-H. (2009) NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity. Molecular Cancer Research Aug;7(8):1408-15. https://doi.org/10.1158/1541-7786.MCR-08-0533.
1、《BIOCHEMISTRY》 （《生物化學》），清華大學出版社，2021高等教育“十三五”規劃教材（英文版），全國高等醫藥院校規劃教材；
2、《能量整合醫學——線粒體ATP中西醫基礎與臨床》，同濟大學出版社，“十四五”時期國家重點出版物出版專項規劃項目。
1、美國國立衛生研究院/美國國立癌症研究所，癌症傑出研究專項基金(SPORE頭頸部腫瘤）培養項目獎 （P50CA128613），2012-2013，$10,000。研究項目：線粒體丙酮酸脫氫酶複合體在頭頸部腫瘤代謝中作用機制研究（項目負責人）。
2、美國癌症協會，研究所研究基金獎，2016-2017，$30,000。研究項目：靶向乙酰輔酶A乙酰轉移酶1（ACAT1)作為白血病治療新策略的研究（項目負責人）。
3、溫希普慈善晚會學者獎 2016-2017，$22,000。研究項目：靶向乙酰輔酶A乙酰轉移酶1（ACAT1)治療白血病研究（項目負責人）。
4、國家自然科學基金委 面上項目（主持），2020-2023。
5、廣東省自然科學基金委 面上項目 （主持），2020-2022。
6、廣東省自然科學基金委 面上項目 （主持），2023-2025。
7、廣東省重大人才工程高層次人才引進項目（主持），2020。
8、蘇州市醫學會醫學科技獎，2021。
9、太阳集团app首页教育教學成果獎，二等獎，2021。
1、廣東省生物化學與分子生物學學會，副理事長（2023- ）
2、廣東省醫學教育協會生殖與遺傳專業委員會，副主任委員（2023-）
3、廣東省藥理學會腫瘤藥理專業委員會常務委員（2019-）
4、中國抗癌協會腫瘤代謝專業委員會微環境專家組全國委員（2021-）
5、中國細胞生物學學會細胞代謝分會常務委員（2019-）
6、廣東省藥理學會内分泌代謝病藥理專業委員會常務委員（2022-）
