朱麗紅

病理生理學系 教授

個人簡介


職稱:教授

學科專業:病理生理學

研究方向:

1. 腦部微環境、神經膠質細胞功能與神經退行性疾病

2. 神經退行性疾病的早期診斷、發病機制及治療幹預

3. 神經炎症與記憶損傷修複關系 

4. 中藥有效成分防治腦功能疾病  

行政職務:病理生理學系副主任

電子郵箱:lhzhu@jnu.edu.cn

個人簡介:

朱麗紅,教授,博導,現任太阳集团1088vip病理生理學系副主任,國家中醫藥管理局重點實驗室副主任。廣東省病理生理學重點學科腦的功能與疾病研究方向的學術骨幹成員,中國病理生理學會、廣東省病理生理學會委員,廣東省保健協會老年性癡呆醫養融合分會委員,科技部、國家自然科學基金委、廣東省科技廳、廣州市科技局專家庫專家,Neuroimmunomodulation/Brain research等多家雜志審稿人。

從事基礎醫學教研工作,不斷改進教學方法和手段,在教材、精品課程和教學團隊建設方面開展了大量工作,入選廣東省優秀青年教師、廣州市珠江科技新星,榮獲太阳集团app首页本科教學校長獎、優秀教學工作者、學生最喜歡的老師等。注重将基礎醫學與臨床醫學、信息光子學、生命科學等跨學科合作,從臨床發掘實際科學問題,解決關鍵科學與技術瓶頸問題,注重構建多元化的發展。近年主持、參與承擔國家、省部級30餘項科研項目,包括國家自然科學基金項目、973計劃、省部級科研課題等,橫、縱向經費逾400萬,多項省市級教改項目,授權國家發明專利2項,主編、參編多部教材,在“Brain Behav Immun”,“Bioengineering & Translational Medicine”等國際雜志發表研究論文40餘篇。


學習經曆


2009.9-2011.9,太阳集团app首页;

2006.9-2009.6,廣州中醫藥大學


工作


2020.10-至今,太阳集团app首页醫學院病理生理學教研室,教授,碩士生導師,病理生理學系副主任;

2013.10-2020.09,太阳集团app首页醫學院病理生理教研室, 副教授,碩士生導師,病理生理學系副主任,病生實驗室主任/機能實驗室主任;

2011.09-2013.09,太阳集团app首页醫學院病理生理教研室, 講師。


主要論文


1. Lihong Zhu,Renbing Qi,Huadong Wang,Wei Bi, Zhigang Wang, Qi Zeng, Yanru Zhao, Daxiang Lu. Luteolin protects PC12 cells from rotenone-induced apoptosis by decreasing cleaved caspase-3 expression. Neural Regen Res.2010,5(24):1870-1874. 

2. Lihong Zhu, Bi W, Qi RB, Wang HD, Lu DX. Luteolin inhibits microglial inflammation and improves neuron survival against inflammation. Int J Neurosci. 2011,121(6):329-336. 

3. Lihong Zhu, Wei Bi, Renbin Qi, Huadong Wang, Zhigang Wang, Qi Zeng, Yan-ru Zhao, Daxiang Lu. Luteolin reduces primary hippocampal neurons death induced by neuroinflammation. Neurol Res, 2011, 33(9):927-934. 

4. LiHong Zhu, Wei Bi, XiaoDong Liu, JieFen Li, YingYa Wu, BiaoYan Du, YuHui Tan. Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage. Oncology reports, 2011,26(6):1447-1455. 

5. LiHong Zhu, Wei Bi, Dan Lu, ChanJuan Zhang, XiaoMing Shu,DaXiang Lu. Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the NF-kB, MAPK and Akt pathways in LPS-stimulated co-cultured BV2 cells. Experimental and Therapeutic Medicine. 2014,7(5):1065-1070.
6. Lihong Zhu, Wei Bi, DAN LU, CHANJUAN ZHANG, XIAOMING SHU and DAXIANG LU Proteomic analysis of luteolin on lipopolysaccharide-stimulated BV2 microglia. Molecular Medicine Reports. Accepted on February 20, 2014.

7. Wei Bi*, Zhu L*(并列第一), Zeng Z, Jing X, Liang Y, Guo L, Shi Q, Xu A, Tao E. Investigations into the role of 26S proteasome non-ATPase regulatory subunit 13 (PSMD13) in neuroinflammation. Neuroimmunomodulation. 2014;21(6):331-337.

8. Wei Bi*, Zhu L*(并列第一), Xiuna Jing, Zhifen Zeng, Yanran Liang, Qiaoyun Shi, Enxiang Tao. Rifampicin improves neuronal apoptosis in LPS-stimulated co-cultured BV2 cells through inhibition of the TLR-4 pathway. Molecular Medicine Reports. 2014,10(4):1793-1799.

9. Lihong Zhu#, Wei Bi#, Dan Lu, Chanjuan Zhang, Xiaoming Shu, Huadong Wang, Renbing Qi , Qiaoyun Shi, Daxiang Lu*. Regulation of Ubiquitin-Specific Processing Protease 8 Suppresses Neuroinflammation Molecular and Cellular Neuroscience.2015,1(64):74-83. 

10. Lu D, Xu A, Mai H, Zhao J, Zhang C, Qi R, Wang H, Lu D, Zhu L. The Synergistic Effects of Heat Shock Protein 70 and Ginsenoside Rg1 against Tert-Butyl Hydroperoxide Damage Model In Vitro. Oxid Med Cell Longev. 2015:437127.

11.Jiayi Zhao , Wei Bi , Shu Xiao , Xin Lan , Xiaofeng Cheng, Jiawei Zhang, Daxiang Lu, Wei Wei , Yanping Wang , Hongmei Li , Yongmei Fu, Lihong Zhu*. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Scientific reports.2019,9:5790.

12.Wei Bi, Xin Lan, JiaWei Zhang, Shu Xiao, XiaoFeng Cheng, HuaDong Wang, DaXiang Lu, and Lihong Zhu*. USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy. Brain research. 2019.1719,40-48. 

13.Zhao J, Bi W, Zhang J, Xiao S, Zhou R, Tsang CK, Lu D, Zhu L*. USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in mice.Brain Behav Immun. 2020,4(19)31562

14. Wei Bi, Xiaofeng Cheng, Zhaohao Zeng, Ruiyi Zhou, Rixin Luo, Jiawei Zhang, Lihong Zhu*. Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF-κB signaling pathway in mice. Neurological research.2020.1866353.

15. Lihong Zhu#, Qiongru Yuan#, Zhaohao Zeng, Ruiyi Zhou, Rixin Luo, Jiawei Zhang,Chikwan Tsang, Wei Bi*.Rifampicin suppresses Aβ accumulation through enhancing autophagy in models of lipopolysaccharide-induced cognitive decline.JOURNAL OF ALZHEIMER’S DISEASE.2021.79,1171-1184.

16.Lihong Zhu#, Ruiyi Zhou #, Zhaohao Zeng, Rixin Luo, Jiawei Zhang, Rui Guo, Lei Zhang, Qunying Zhang, Wei Bi.Targeted Brain Delivery of RVG29-Modified Rifampicin-Loaded Nanoparticles for Alzheimer Disease Treatment and Diagnosis.Bioengineering & Translational Medicine.2022.18


學術著作


1.《病理生理學實驗指導及病例分析》,主編。


獲獎及榮譽


1.入選太阳集团app首页醫學院“十二五”科技創新重點培養對象 

2.入選太阳集团app首页“優秀青年教師”支持計劃(第二層次)

3.入選第八批廣東省高等學校“千百十工程”校級培養對象 

4.入選太阳集团app首页“優秀青年教師”支持計劃(第一層次) 

5.入選廣州市2015年珠江科技新星專項  

6.入選廣東省高等學校優秀青年教師培養計劃人才專項 

7.入選“暨南雙百英才計劃”暨南傑出青年學者支持計劃(第一層次) 

8.第六屆本科課程教學競賽獲太阳集团app首页醫學院一等獎 

9.第六屆本科課程教學競賽獲太阳集团app首页二等獎 

10.2020年線上微課教學競賽獲基礎醫學院一等獎

11.2021年,第七屆“太阳集团app首页本科教學校長獎”,青年教師綜合獎獲得者。

12.2021年,學院年度榮譽獎項評選,榮獲“優秀教學工作者”,“學生最喜歡的老師”。




學術兼職


1、國家自然科學基金評審專家

2、中國病理生理學會委員

3、廣東省病理生理學會青年委員

4、廣東省保健協會老年性癡呆醫養融合分會委員