人體解剖學 教授
職稱：教授
學科專業：人體解剖學
研究方向：認知、情緒及發育障礙的神經環路和突觸可塑性機制
行政職務：人體解剖學系主任；認知與發育障礙神經科學創新實驗室主任
電子郵箱：tgqguo@jnu.edu.cn
個人介紹：郭國慶，研究生學曆，博士學位，教授，博士導師，解剖學系主任。1989年畢業于河南新鄉醫學院；1995年中山醫科大學獲碩士學位，師從解剖學家邝國璧教授；2007年南方醫科大學獲博士學位，師從解剖學家鐘世鎮院士；2003年受聘為太阳集团app首页醫學院副教授、碩士生導師，2010年受聘教授、博士生導師。一直從事人體解剖學的教學和科研工作，研究興趣在于用形态學、分子生物學、光遺傳學、在體電生理、細胞和腦片膜片鉗以及行為學等技術解析認知與發育障礙相關神經系統疾病的環路機制及樹突棘可塑性機制。主持國家自然科學基金3項，廣東省自然科學基金3項、省重點項目1項、其他各類科學基金9項；以通訊作者發表在Neuropsychopharmacology、Translational Psychiatry、Neurobiology of Disease等國際期刊發表SCI論文40餘篇，獲河南省教育廳科技二等獎1項。
座右銘：科學研究需要興趣，也需要耐心、踏實和努力。
2010.10-至今，廣州太阳集团app首页醫學院解剖學系，教授
2004.09-2007.06，廣州南方醫科大學基礎醫學院人體解剖學專業，獲醫學博士學位
1995.07-2010.10，廣州太阳集团app首页醫學院解剖學系，助教，講師，副教授
1992.09-1995.06，廣州中山醫科大學人體解剖學專業，獲醫學碩士學位
1989.07-1992.08，河南新鄉醫學院基礎醫學部，助教
1984.09-1989.06，河南新鄉醫學院臨床醫學系兒科專業，獲醫學學士學位
[1] Li F#, Zheng X#, Wang H, Meng L, Chen M, Hui Y, Liu D, Xie K, Zhang J*, Guo G*. Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors. Neuropsychopharmacology. 2024. https://doi.org/10.1038/s41386-024-01829-y.
[2] Zhang W#, Zhang J#, Zhang Z#, Cha S, Li J, Chen L, Wu J, Teng J, Guo G*, Zhang J*. Effects of deSUMOylated spastin on AMPA receptor surface delivery and synaptic function are enhanced by phosphorylating at Ser210. Mol Neurobiol. 2024. doi: 10.1007/s12035-024-03935-w.
[3] Zhang H#, Yu G#, Li J#, Tu C, Hui Y, Liu D, Chen M, Zhang J*, Gong X*, Guo G*. Overexpressing lnc240 rescues learning and memory dysfunction in hepatic encephalopathy through miR-1264-5p/MEF2C axis. Mol Neurobiol. 2023, 60(4): 2277-2294.
[4] Chen M#, Jiang Y#, Li X#, Li J, Tu C, Zhang H, Gong X, Yu G*, Guo G*, Zhang J*. Enriched environment ameliorates learning and memory deficits in hepatic encephalopathy mice by restoration of the structure of dendrites and dendritic spines. Brain Res. 2023, 1804: 148264.
[5] Wang H#, Li F#, Zheng X#, Meng L, Chen M, Hui Y, Li Y, Xie K, Zhang J*, Guo G*. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice. Transl Psychiatry. 2022, 12(1):380.
[6] Zhu W#, Wu F#, Li J, Meng L, Zhang W, Zhang H, Cha S, Zhang J*, Guo G*. Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function. Neurobiol Dis. 2022, 171:105807.
[7] Zhang J#, Zilundu PLM#, Fu R, Zheng X, Zhou L*, Guo G*. Medical students' perceptions and performance in an online regional anatomy course during the Covid-19 pandemic. Anat Sci Educ. 2022, 15(5):928-942.
[8] Zhang J#,, Zilundu PLM#,, Zhang W#,, Yu G, Li S, Zhou L*, Guo G*. The use of a surgical boot camp combining anatomical education and surgical simulation for internship preparedness among senior medical students. BMC Med Educ. 2022, 22(1): 459.
[9] Zhu W#, Wu F#, Hu J, Wang W, Zhang J*, Guo G*. Structural investigation of the interaction mechanism between chlorogenic acid and AMPA receptor via in silico approaches. Molecules. 2022, 27(11): 3394.
[10] Zhang H#, Zhang W#, Yu G#, Li F, Hui Y, Cha S, Chen M, Zhu W, Zhang J*, Guo G*, Gong X*. Comprehensive analysis of lncRNAs, miRNAs and mRNAs in mouse hippocampus with hepatic encephalopathy. Front Genet. 2022, 13:868716.
[11] Hui Y#, Zheng X#, Zhang H#, Li F, Yu G, Li J, Zhang J*, Gong X*, Guo G*. Strategies for targeting neural circuits: how to manipulate neurons using virus vehicles. Front Neural Circuits. 2022,16: 882366.
[12] Cheng L#, Chen K#, Li J#, Wu J, Zhang J, Chen L, Guo G*, Zhang J*. Phosphorylation of CRMP2 by Cdk5 negatively regulates the surface delivery and synaptic function of AMPA receptors. Mol Neurobiol. 2022, 59(2): 762-777.
[13] Chen L#, Wang H#, Cha S#, Li J, Zhang J, Wu J, Guo G*, Zhang J*. Phosphorylation of spastin promotes the surface delivery and synaptic function of AMPA receptors. Front Cell Neurosci. 2022, 16:809934.
[14] Li S#, Zhang J#, Zhang J#, Li J, Cheng L, Chen L, Cha C*, Guo G*. Spastin interacts with CRMP2 to regulate neurite outgrowth by controlling microtubule dynamics through phosphorylation modifications. CNS Neurol Disord Drug Targets, 2021, 20(3):249-265.
[15] Zhang J#, Zilundu PLM, Zhou L, Guo G*. Supplementary regional anatomy teaching by surgeons enhances medical students mastery of anatomical knowledge and positively impacts their choice of future career. J Surg Educ. 2020, 77(5):1113-1120.
[16] Zhang J#, Li J#, Yin Y#, Li X, Jiang Y, Wang Y, Cha C*, Guo G*. Collapsin response mediator protein 2 and endophilin2 coordinate regulation of AMPA receptor GluA1 subunit recycling. Front Mol Neurosci, 2020, 13: 128.
[17] Ji Z#, Liu Q#, Zhang J, Yang Y, Li J, Zhang G, Tan M*, Lin H*, Guo G*. SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics. Neurobiol Dis. 2020, 146:105133.
[18] Li J#, Wu F#, Cheng L, Zhang J, Cha C, Chen L, Feng T, Zhang J*, Guo G*. A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule severing function. Mol Med Rep. 2020, 21(6): 2367-2374.
[19] Zhang Z#, Zhang J#, Li J, Zhang J, Chen L, Li Y*, Guo G*. Ketamine regulates phosphorylation of CRMP2 to mediate dendritic spine plasticity. J Mol Neurosci, 2020, 70(3): 353-364.
[20]Wang C, Huang X, Wu Y, Wang J, Li F*, Guo G*. Tumor cell-associated exosomes robustly elicit anti-tumor immune responses through modulating dendritic cell vaccines in lung tumor. Int J Biol Sci. 2020, 16(4):633-643.
[21] Yin Y#, Cha C#, Wu F, Li J, Li S, Zhu X, Zhang J*, Guo G*. Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. Mol Med Rep, 2019, 19(6): 4897-4905.
[22] Zhang J#, Zhao B#, Zhu X#, Li J, Wu F, Li S, Gong X, Cha C*, Guo G*. Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines. Brain Res Bull. 2018, 139: 21-30.
[23] Zhang J#, Yin Y#, Ji Z, Cai Z, Zhao B, Li J, Tan M*, Guo G*. Endophilin2 interacts with GluA1 to mediate AMPA receptor endocytosis induced by oligomeric amyloid-β. Neural Plast, 2017, 2017：8197085.
[24] Cha C#, Zhang J#, Ji Z, Tan M, Li S, Wu F, Chen K, Gong S, Guo G*, Lin H*. CRMP4 regulates dendritic growth and maturation via the interaction with actin cytoskeleton in cultured hippocampal neurons. Brain Res Bull, 2016, 124: 286-94.
[25] Zhang J#, Tan M#, Yin Y, Ren B, Jiang N, Guo G*, Chen Y*. Distinct functions of endophilin isoforms in synaptic vesicle endocytosis. Neural Plast. 2015, 371496.
1.《系統解剖學》. 華中科技大學出版社，2023年.（主編）
2.《系統解剖學實驗教程》華中科技大學出版社，2023年.（副主編）
3.《人體解剖生理學》. 北京大學醫學出版社，2020年.（主編）
4.《系統解剖學實驗指導》.北京大學醫學出版社，2018年.（主編）
5.《Grant解剖學操作指南》(第17版). 北京科學技術出版社，2022年. (參譯)
6.《系統解剖學》(第2版). 高等教育出版社，2020年. (參編)
7.《系統解剖學》. 世界知識出版社，2002年. (參編)
8.《系統解剖學學習指導》. 世界知識出版社，2002年. (參編)
9.《系統解剖學》. 高等教育出版社，2014年. (參編)
10.《科技文獻檢索與利用》 科學出版社，2014年. (參編)
11.《Grant解剖學操作指南》(第15版). 北京科學技術出版社，2016年. (參譯)
1.第十屆太阳集团app首页高等教育教學成果特等獎，第一完成人
2.廣東省線下一流本科課程《系統解剖學》，負責人
3.外科醫生走進局部解剖學課堂有助于知識掌握和未來職業規劃, 獲得全國高等院校第五屆實驗教學及實驗技術工作者優秀論文一等獎（通訊作者）
廣東省精準醫學應用學會數字醫學分會 副主任委員
廣東省解剖學會第十四屆理事會 常務理事
中國臨床解剖學雜志 編委
中國解剖學會第十七屆理事會虛拟現實分會 常務委員
中國醫師協會顯微外科醫師分會第二屆委員會顯微基礎研究學組 委員
廣東省神經科學學會 理事
